Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8701
Gene Symbol: DNAH11
DNAH11 		0.400 CausalMutation phenotype CLINVAR
Entrez Id: 55252
Gene Symbol: ASXL2
ASXL2 		0.100 CausalMutation phenotype CLINVAR
Entrez Id: 64324
Gene Symbol: NSD1
NSD1 		0.100 CausalMutation phenotype CLINVAR
Entrez Id: 5530
Gene Symbol: PPP3CA
PPP3CA 		0.100 CausalMutation phenotype CLINVAR
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.300 Therapeutic phenotype CTD_human Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins. 21561152 2011
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.300 Therapeutic phenotype CTD_human A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. 19716478 2009
Entrez Id: 5467
Gene Symbol: PPARD
PPARD 		0.300 Therapeutic phenotype CTD_human Telmisartan prevents weight gain and obesity through activation of peroxisome proliferator-activated receptor-delta-dependent pathways. 20176998 2010
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.300 Therapeutic phenotype CTD_human IL-33 Drives Augmented Responses to Ozone in Obese Mice. 27472835 2017
Entrez Id: 412
Gene Symbol: STS
STS 		0.300 Therapeutic phenotype CTD_human Hepatic overexpression of steroid sulfatase ameliorates mouse models of obesity and type 2 diabetes through sex-specific mechanisms. 24497646 2014
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.300 Therapeutic phenotype CTD_human Thus, variation in the leptin gene may be a risk factor for weight gain in male patients with schizophrenia on long-term clozapine treatment. 17502770 2007
Entrez Id: 29108
Gene Symbol: PYCARD
PYCARD 		0.300 Therapeutic phenotype CTD_human Activation of inflammasomes in podocyte injury of mice on the high fat diet: Effects of ASC gene deletion and silencing. 24508291 2014
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.300 Therapeutic phenotype CTD_human Role for fatty acid amide hydrolase (FAAH) in the leptin-mediated effects on feeding and energy balance. 29967158 2018
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.300 Therapeutic phenotype CTD_human Oral administration of Nitraria retusa ethanolic extract enhances hepatic lipid metabolism in db/db mice model 'BKS.Cg-Dock7(m)+/+ Lepr(db/)J' through the modulation of lipogenesis-lipolysis balance. 25086370 2014
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.300 Therapeutic phenotype CTD_human Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. 15070752 2004
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.300 Therapeutic phenotype CTD_human Increased HO-1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21. 23839791 2014
Entrez Id: 284207
Gene Symbol: METRNL
METRNL 		0.300 Therapeutic phenotype CTD_human Furthermore, METRNL administration rescued glucose intolerance and reduced HFD-induced body weight gain in mice; however, METRNL did not affect calorie intake. 30213948 2018
Entrez Id: 6319
Gene Symbol: SCD
SCD 		0.200 Therapeutic phenotype CTD_mouse Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia. 21661758 2011
Entrez Id: 8701
Gene Symbol: DNAH11
DNAH11 		0.400 Biomarker phenotype CTD_human Different transcriptional control of metabolism and extracellular matrix in visceral and subcutaneous fat of obese and rimonabant treated mice. 19030233 2008
Entrez Id: 3620
Gene Symbol: IDO1
IDO1 		0.300 Biomarker phenotype CTD_human Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1. 27020609 2016
Entrez Id: 857
Gene Symbol: CAV1
CAV1 		0.300 Biomarker phenotype CTD_human Different transcriptional control of metabolism and extracellular matrix in visceral and subcutaneous fat of obese and rimonabant treated mice. 19030233 2008
Entrez Id: 51449
Gene Symbol: PCYOX1
PCYOX1 		0.300 Biomarker phenotype CTD_human Different transcriptional control of metabolism and extracellular matrix in visceral and subcutaneous fat of obese and rimonabant treated mice. 19030233 2008
Entrez Id: 586
Gene Symbol: BCAT1
BCAT1 		0.300 Biomarker phenotype CTD_human Different transcriptional control of metabolism and extracellular matrix in visceral and subcutaneous fat of obese and rimonabant treated mice. 19030233 2008
Entrez Id: 4811
Gene Symbol: NID1
NID1 		0.300 Biomarker phenotype CTD_human Different transcriptional control of metabolism and extracellular matrix in visceral and subcutaneous fat of obese and rimonabant treated mice. 19030233 2008
Entrez Id: 9518
Gene Symbol: GDF15
GDF15 		0.300 Biomarker phenotype CTD_human Different transcriptional control of metabolism and extracellular matrix in visceral and subcutaneous fat of obese and rimonabant treated mice. 19030233 2008
Entrez Id: 6711
Gene Symbol: SPTBN1
SPTBN1 		0.300 Biomarker phenotype CTD_human Different transcriptional control of metabolism and extracellular matrix in visceral and subcutaneous fat of obese and rimonabant treated mice. 19030233 2008